In the heart of Fisherman’s Wharf, this Applebee’s is San Francisco’s first — and likely only — outpost. With 12,000-square-feet of dining space fitting up to 400 seats, it's also one of the largest Applebee's in the world.  Applebee's menu features beef, chicken and pork items, as well as burgers, pasta and seafood, with a selection of signature menu items found only at Applebee's. The Pick 'N Pair Lunch Combos are especially popular for the busy lunchtime crowd, offering more than 60 different combinations.